It suggests interactions with lansoprazole and pantoprazole as less pronounced
The clopidogrel-PPI interaction: an updated mini-review Proton pump inhibitors (PPIs) are recommended in patients with prior upper gastrointestinal bleeding and considered
To the Editor: The label for clopidogrel warns physicians to “avoid concomitant use of
Published May 27, 2021 Last updated Feb 18, 2024 Key points Omeprazole can reduce the activity of Plavix, making it less effective and increase your risk of serious cardiovascular
These other drugs come in both brand name and generic versions
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Medications like proton pump inhibitors (PPIs), fluoxetine (Prozac), and fluconazole (Diflucan) can make clopidogrel less effective
The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%
Proton pump inhibitors are thought to dimin-ish the activity of clopidogrel via inhibition of the CYP2C19 isoenzyme
Omeprazole has inhibitory effects and is metabolized by CYP450 2C19, therefore, potentially limiting the active form of clopidogrel and its antiplatelet effects
Although a diminished pharmacodynamic effect of clopidogrel has been demonstrated in patients treated with proton-pump inhibitors (PPIs), whether its clinical efficacy is reduced remains Find out about possible interactions between Plavix and other medications, supplements, alcohol, foods, and more
The earliest evidence suggesting an interaction between PPIs and clopidogrel involved a study of 105 patients receiving aspirin and clopidogrel after high-risk angioplasty
4 Decreases in bleeding times and increases in platelet reactivity index were also observed, consistent with a reduction in anti-clotting ability
A national study of the effect of individual proton pump inhibitors on cardiovascular outcomes in patients treated with clopidogrel following coronary stenting: The Clopidogrel
Theoretically, the active form of clopidogrel should be decreased by concomitant treatment with CYP2C19 inhibitors
omeprazole; pantoprazole; potassium chloride; prednisone; Protonix (pantoprazole) simvastatin; Synthroid (levothyroxine) tramadol; Clopidogrel (Plavix ®) is a drug used to decrease platelet functioning to prevent undesired arterial blood clots
Dexlansoprazole, lansoprazole, and pantoprazole had less pronounced effects on the antiplatelet activity of Plavix than did omeprazole or esomeprazole [see DRUG INTERACTIONS]
Proton pump inhibitors (PPIs), commonly used for prophylaxis and treatment of gastrointestinal bleeding, have been shown to inhibit the cytochrome P450 2C19 pathway to various degrees